So, I'd say true randomness in nature is essential for nature to keep the future sealed, to keep the wool over our eyes.
In physics, such on the quantum level where particles can take path A or B - the paths are both similar and there is no reason why it would take one over the other, nothing governing it to take one over the other. So, it seems random. But it always keeps its internal order with whatever path it takes over the other. What prompts it do take that path? We don't really know, it seems random.
This is interesting, because for one it doesn't seem to matter that randomness is a factor, because everything in the end will be deterministic in a way, predictable. However what paths things take we can not determine. This allows for freedom of choice in a way. For non-living things this would be simply random processes vs natural laws which yield non random processes. BUT in living things, while we start out random (like bacteria until it finds an attractant) we end up non random because of memory and consciousness. Freedom to choose.
See, it is important for a certain level of randomness to exist to allow for us true freedom of choice. If everything was deterministic and everything could be predicted, than everything would be set for us and we truly would have no freedom of choice.
This does show us that on a fundamental level, on a small level, nature is and can be very random and this is important.
Nature fulfills a chain of events —in time— much like our memory fulfills a series of events. As nature does this, or own memory does this, things seem to go from random to non random. Simple to complex. From Nothingness (chaos of virtual particles) into something. BUT there is a direction, an internal innate drive.
Energy seems to go from randomness to non-randomness as energies increase and become more complex. (This can also be found in the new theories of dynamic energy).
The true nature of randomness allows the future to be unseen while also allowing for true freedom of choice.
HOWEVER--while mathematicians prefer the definition above to that of unpredictability, biological scientists like to use randomness to mean something without purpose or goal.
This is where the problem comes in for many people who see there is something more than just the physical world we can measure scientifically/naturally.
How are we defining the terms?
Nature has its own way to do things, whether we understand them or not. What scientists are looking at is nature- not a spirit or a God.
A marble in itself doesn't have a purpose or goal because it has no consciousness. But this does not mean the marble was not put in place by something with a higher energy and understanding than ourselves.
Also- energy persists toward entropy and life persists toward survival. This seems to be fundamental, inside the very core of all things, innate. This is a purpose and goal. It might not be a conscious one or an external one, but it certainly appears to be an internal one. Just something nature does.
So, even if there is no higher energy "God" which put the marble into place, there certainly is an internal purpose and goal. Be it a very simple one. Life persists TO EXIST. TO BE. And while energy heads toward entropy, it still bothered to exist at all. Why does it?
So, While I have no problems understanding the mathematical ideas of randomness, biologists seem to cross the line and take it a step further into realms they cannot prove or disprove and so are walking out of the very bounds of science.
And in fact I'd say Nature, even without proving a God, does have a internal purpose and goal. So, that idea just is not correct naturally or even when we consider the possibility that a "God" is behind it.
What about guidance?
I don't think God interferes with the natural world which is what many call guidance. I think God put everything into place exactly as it is and it is self-sufficient without the constant need of intervention.
However, I do think where we see the Spirit or God is in people's lives. The spirit can affect our minds, dreams, emotions and can speak to us and it is in this where we will find guidance.